Design and Analysis of DNA Microarray Investigations

Design and Analysis of DNA Microarray Investigations PDF Author: Richard M. Simon
Publisher:
ISBN: 9781475781106
Category :
Languages : en
Pages : 232

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Design and Analysis of DNA Microarray Investigations

Design and Analysis of DNA Microarray Investigations PDF Author: Richard M. Simon
Publisher: Springer Science & Business Media
ISBN: 0387218661
Category : Medical
Languages : en
Pages : 200

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Book Description
The analysis of gene expression profile data from DNA micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.

Environmental Health Perspectives

Environmental Health Perspectives PDF Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages :

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DNA Microarrays and Related Genomics Techniques

DNA Microarrays and Related Genomics Techniques PDF Author: David B. Allison
Publisher: Chapman and Hall/CRC
ISBN: 9780824754617
Category : Mathematics
Languages : en
Pages : 392

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Book Description
Considered highly exotic tools as recently as the late 1990s, microarrays are now ubiquitous in biological research. Traditional statistical approaches to design and analysis were not developed to handle the high-dimensional, small sample problems posed by microarrays. In just a few short years the number of statistical papers providing approaches to analyzing microarray data has gone from almost none to hundreds if not thousands. This overwhelming deluge is quite daunting to either the applied investigator looking for methodologies or the methodologist trying to keep up with the field. DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments consolidates discussions of methodological advances into a single volume. The book’s structure parallels the steps an investigator or an analyst takes when conducting and analyzing a microarray experiment from conception to interpretation. It begins with foundational issues such as ensuring the quality and integrity of the data and assessing the validity of the statistical models employed, then moves on to cover critical aspects of designing a microarray experiment. The book includes discussions of power and sample size, where only very recently have developments allowed such calculations in a high dimensional context, followed by several chapters covering the analysis of microarray data. The amount of space devoted to this topic reflects both the variety of topics and the effort investigators have devoted to developing new methodologies. In closing, the book explores the intellectual frontier – interpretation of microarray data. It discusses new methods for facilitating and affecting formalization of the interpretation process and the movement to make large high dimensional datasets public for further analysis, and methods for doing so. There is no question that this field will continue to advance rapidly and some of the specific methodologies discussed in this book will be replaced by new advances. Nevertheless, the field is now at a point where a foundation of key categories of methods has been laid out and begun to settle. Although the details may change, the majority of the principles described in this book and the foundational categories it contains will stand the test of time, making the book a touchstone for researchers in this field.

All of Statistics

All of Statistics PDF Author: Larry Wasserman
Publisher: Springer Science & Business Media
ISBN: 0387217363
Category : Mathematics
Languages : en
Pages : 442

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Book Description
Taken literally, the title "All of Statistics" is an exaggeration. But in spirit, the title is apt, as the book does cover a much broader range of topics than a typical introductory book on mathematical statistics. This book is for people who want to learn probability and statistics quickly. It is suitable for graduate or advanced undergraduate students in computer science, mathematics, statistics, and related disciplines. The book includes modern topics like non-parametric curve estimation, bootstrapping, and classification, topics that are usually relegated to follow-up courses. The reader is presumed to know calculus and a little linear algebra. No previous knowledge of probability and statistics is required. Statistics, data mining, and machine learning are all concerned with collecting and analysing data.

Advanced Techniques in Diagnostic Microbiology

Advanced Techniques in Diagnostic Microbiology PDF Author: Yi-Wei Tang
Publisher: Springer
ISBN: 3319339001
Category : Medical
Languages : en
Pages : 541

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Book Description
In recent years, advanced molecular techniques in diagnostic microbiology have been revolutionizing the practice of clinical microbiology in the hospital setting. Molecular diagnostic testing in general and nucleic acid-based amplification methods in particular have been heralded as diagnostic tools for the new millennium. This third edition covers not only the most recent updates and advances, but details newly invented omic techniques, such as next generation sequencing. It is divided into two distinct volumes, with Volume 1 describing the techniques, and Volume 2 addressing their applications in the field. In addition, both volumes focus more so on the clinical relevance of the test results generated by these techniques than previous editions.

Application of Solution Protein Chemistry to Biotechnology

Application of Solution Protein Chemistry to Biotechnology PDF Author: Roger L. Lundblad
Publisher: CRC Press
ISBN: 1420073427
Category : Medical
Languages : en
Pages : 456

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Book Description
Reflecting the versatility of the author’s science and the depth of his experience, Application of Solution Protein Chemistry to Biotechnology explores key contributions that protein scientists can make in the development of products that are both important and commercially viable, and provides them with tools and information required for successful participation. One of the of the world’s most respected protein researchers, Roger Lundblad does not succumb to the notion that new is always better. The application of protein science to the practice of commercial biotechnology is traced to the underlying basic solution protein chemistry. It is only by achieving this understanding that the full potential of protein science may be obtained in the development and characterization of the diverse products of modern biotechnology. Dr. Lundblad also goes far beyond the biopharmaceutical applications that are often equated with protein science today to demonstrate the field’s unique versatility. From the making of bread and the invention of adhesives to the production of pharmaceuticals and the development of recombinant DNA products— in each of these products, the role of the protein chemist remains prominent. The important point is that classical protein chemistry is a critical part of the practice of biotechnology in the marketplace. Providing the direction and the foundational work needed by students as well as the details and hundreds of references needed by designers and developers, this remarkable work— Delves into the application of protein science for producing products as diverse as adhesives, drug delivery systems, and quality food products Explores chemistry of attachment of proteins and peptides to solid surfaces with regard to applications both for the improvement of steel and titanium and in DNA and protein microarrays Describes the development of bioconjugates used in antibodies Offers essential advice on guidelines required for producing licensed biopharmaceutical products While he does include a great deal of material not found in other sources, Dr. Lundblad makes a point to separate what is truly new from that which has merely been renamed. A reference unlike most, scientists and students eager to learn will find a text that is as practical as it is purposeful.

Epigenetic Epidemiology

Epigenetic Epidemiology PDF Author: Karin B. Michels
Publisher: Springer Science & Business Media
ISBN: 9400724942
Category : Medical
Languages : en
Pages : 448

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Book Description
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Microarrays

Microarrays PDF Author: Jang B. Rampal
Publisher: Springer Science & Business Media
ISBN: 1588295893
Category : Medical
Languages : en
Pages : 452

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Book Description
Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications. The first volume deals with methods and protocols for the preparation of microarrays. The second volume details applications and data analysis, which is important in analyzing the enormous data coming out of microarray experiments. Among the topics discussed in Volume 1: Synthesis Methods, are matrices in the synthesis of microarrays, array optimization processes, array-based comparative genomic hybridization, 60-mer oligonucleotide probes, bifunctional reagents NTMTA and NTPAC, and high density arrays using digital microarray synthesis platforms. Other topics include multiplex ligation-dependent probe amplification (MLPA), hybridization conditions in situ-synthesized oligo arrays, peptide arrays, high density replication tools (HDRT), protocols for the quantification of oligo hybridization, glyco-bead arrays, and an investigation into the emerging nano technology. Microarray Technology, Volumes 1 and 2, provide ample information to all levels of scientists from novice to those intimately familiar with array technology.

Parallel Computing for Bioinformatics and Computational Biology

Parallel Computing for Bioinformatics and Computational Biology PDF Author: Albert Y. Zomaya
Publisher: John Wiley & Sons
ISBN: 0471756490
Category : Computers
Languages : en
Pages : 1000

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Book Description
Discover how to streamline complex bioinformatics applications withparallel computing This publication enables readers to handle more complexbioinformatics applications and larger and richer data sets. As theeditor clearly shows, using powerful parallel computing tools canlead to significant breakthroughs in deciphering genomes,understanding genetic disease, designing customized drug therapies,and understanding evolution. A broad range of bioinformatics applications is covered withdemonstrations on how each one can be parallelized to improveperformance and gain faster rates of computation. Current parallelcomputing techniques and technologies are examined, includingdistributed computing and grid computing. Readers are provided witha mixture of algorithms, experiments, and simulations that providenot only qualitative but also quantitative insights into thedynamic field of bioinformatics. Parallel Computing for Bioinformatics and Computational Biology isa contributed work that serves as a repository of case studies,collectively demonstrating how parallel computing streamlinesdifficult problems in bioinformatics and produces better results.Each of the chapters is authored by an established expert in thefield and carefully edited to ensure a consistent approach and highstandard throughout the publication. The work is organized into five parts: * Algorithms and models * Sequence analysis and microarrays * Phylogenetics * Protein folding * Platforms and enabling technologies Researchers, educators, and students in the field of bioinformaticswill discover how high-performance computing can enable them tohandle more complex data sets, gain deeper insights, and make newdiscoveries.