Dna Microarrays As a Tool in Cancer Research

Dna Microarrays As a Tool in Cancer Research PDF Author: Antti Kokko
Publisher: LAP Lambert Academic Publishing
ISBN: 9783838318493
Category :
Languages : en
Pages : 88

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Book Description
DNA microarray technology has been rapidly adopted by biomedical researchers and emerged as a promising research method in studies of human cancer. In many cases in silico data alone is not sufficient to identify a cancer predisposing gene, but when used together with other methods such as linkage analysis and functional studies this becomes a very prominent tool. This study describes various methods used in microarray technology and how the technology was utilized in studies of certain hereditary cancers together with supporting methods and technologies. Although DNA microarrays are used primarily in research, clinical applications are foreseeable and slowly emerging. This study should give more insight to the potential of microarrays as a tool for cancer research. The book should be especially useful for undergraduate or graduate students in the field of molecular biology or cancer research who wish to know more about the microarray technology and how it may be used in conjunction with other methods in genetics, or for anyone else who may be interested in microarray experiments.

Dna Microarrays As a Tool in Cancer Research

Dna Microarrays As a Tool in Cancer Research PDF Author: Antti Kokko
Publisher: LAP Lambert Academic Publishing
ISBN: 9783838318493
Category :
Languages : en
Pages : 88

View

Book Description
DNA microarray technology has been rapidly adopted by biomedical researchers and emerged as a promising research method in studies of human cancer. In many cases in silico data alone is not sufficient to identify a cancer predisposing gene, but when used together with other methods such as linkage analysis and functional studies this becomes a very prominent tool. This study describes various methods used in microarray technology and how the technology was utilized in studies of certain hereditary cancers together with supporting methods and technologies. Although DNA microarrays are used primarily in research, clinical applications are foreseeable and slowly emerging. This study should give more insight to the potential of microarrays as a tool for cancer research. The book should be especially useful for undergraduate or graduate students in the field of molecular biology or cancer research who wish to know more about the microarray technology and how it may be used in conjunction with other methods in genetics, or for anyone else who may be interested in microarray experiments.

Cancer Diagnostics with DNA Microarrays

Cancer Diagnostics with DNA Microarrays PDF Author: Steen Knudsen
Publisher: John Wiley & Sons
ISBN: 0470041099
Category : Science
Languages : en
Pages : 272

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Book Description
Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

DNA Microarray Technology and Data Analysis in Cancer Research

DNA Microarray Technology and Data Analysis in Cancer Research PDF Author:
Publisher:
ISBN: 981447200X
Category :
Languages : en
Pages :

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Statistics and Informatics in Molecular Cancer Research

Statistics and Informatics in Molecular Cancer Research PDF Author: Carsten Wiuf
Publisher: OUP Oxford
ISBN: 0191579955
Category : Medical
Languages : en
Pages : 208

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Book Description
Molecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences. Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters from carefully chosen experts it brings the reader up to date with specific topics in cancer research, how the topics give rise to development of new informatics and statistics tools, and how the tools can be applied. The focus of the book is to give the reader an understanding of key concepts and tools, rather than focusing on technical issues. A main theme is the extensive use of array technologies in modern cancer research - gene expression and exon arrays, SNP and copy number arrays, and methylation arrays - to derive quantitative and qualitative statements about cancer, its progression and aetiology, and to understand how these technologies on one hand allow us learn about cancer tissue as a complex system and on the other hand allow us to pinpoint key genes and events as crucial for the development of the disease.

Design and Analysis of DNA Microarray Investigations

Design and Analysis of DNA Microarray Investigations PDF Author: Richard M. Simon
Publisher: Springer Science & Business Media
ISBN: 0387218661
Category : Medical
Languages : en
Pages : 200

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Book Description
The analysis of gene expression profile data from DNA micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.

Molecular Pathology in Cancer Research

Molecular Pathology in Cancer Research PDF Author: Sunil R. Lakhani
Publisher: Springer
ISBN: 149396643X
Category : Medical
Languages : en
Pages : 369

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Book Description
The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classification of different tumors and identification of potential molecular targets, as well as how this knowledge may be translated into clinical practice, and the huge impact this field is likely to have in the next 5 to 10 years.

Expression Profiling of Human Tumors

Expression Profiling of Human Tumors PDF Author: Marc Ladanyi
Publisher: Springer Science & Business Media
ISBN: 1592593860
Category : Medical
Languages : en
Pages : 399

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Book Description
A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

Gene Expression Profiling by Microarrays

Gene Expression Profiling by Microarrays PDF Author: Wolf-Karsten Hofmann
Publisher: Cambridge University Press
ISBN: 1139456911
Category : Medical
Languages : en
Pages :

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Book Description
Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means to classify cancer and other diseases. Gene expression profiling can also be used to predict clinical outcome and response to specific therapeutic agents. This survey spans recent applications of microarrays in clinical medicine, covering malignant disease including acute leukaemias, lymphoid malignancies and breast cancer, together with diabetes and heart disease. Investigators in oncology, pharmacology and related clinical sciences, as well as basic scientists, will value this review of a promising new diagnostic and prognostic technology.

Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment

Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309101344
Category : Medical
Languages : en
Pages : 112

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Book Description
Research has long sought to identify biomarkers that could detect cancer at an early stage, or predict the optimal cancer therapy for specific patients. Fueling interest in this research are recent technological advances in genomics, proteomics, and metabolomics that can enable researchers to capture the molecular fingerprints of specific cancers and fine-tune their classification according to the molecular defects they harbor. The discovery and development of new markers of cancer could potentially improve cancer screening, diagnosis, and treatment. Given the potential impact cancer biomarkers could have on the cost effectiveness of cancer detection and treatment, they could profoundly alter the economic burden of cancer as well. Despite the promise of cancer biomarkers, few biomarker-based cancer tests have entered the market, and the translation of research findings on cancer biomarkers into clinically useful tests seems to be lagging. This is perhaps not surprising given the technical, financial, regulatory, and social challenges linked to the discovery, development, validation, and incorporation of biomarker tests into clinical practice. To explore those challenges and ways to overcome them, the National Cancer Policy Forum held the conference "Developing Biomarker-Based Tools for Cancer Screening, Diagnosis and Treatment: The State of the Science, Evaluation, Implementation, and Economics" in Washington, D.C., from March 20 to 22, 2006. At this conference, experts gave presentations in one of six sessions. In addition, seven small group discussions explored the policy implications surrounding biomarker development and adoption into clinical practice. Developing Biomarker-based Tools for Developing Cancer Screening, Diagnosis, and Treatment: The State of the Science, Evaluation, Implementation, and Economics-Workshop Summary presents the conference proceedings and will be used by an Institute of Medicine (IOM) committee to develop consensus-based recommendations for moving the field of cancer biomarkers forward.

Microarrays and Cancer Research

Microarrays and Cancer Research PDF Author: Janet A. Warrington
Publisher: Eaton Publishing Company
ISBN:
Category : Medical
Languages : en
Pages : 162

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