Microarrays and Cancer Research

Microarrays and Cancer Research PDF Author: Janet A. Warrington
Publisher: Eaton Publishing Company
ISBN:
Category : Medical
Languages : en
Pages : 162

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DNA Microarray Technology and Data Analysis in Cancer Research

DNA Microarray Technology and Data Analysis in Cancer Research PDF Author:
Publisher:
ISBN: 981447200X
Category :
Languages : en
Pages :

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Dna Microarrays As a Tool in Cancer Research

Dna Microarrays As a Tool in Cancer Research PDF Author: Antti Kokko
Publisher: LAP Lambert Academic Publishing
ISBN: 9783838318493
Category :
Languages : en
Pages : 88

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DNA microarray technology has been rapidly adopted by biomedical researchers and emerged as a promising research method in studies of human cancer. In many cases in silico data alone is not sufficient to identify a cancer predisposing gene, but when used together with other methods such as linkage analysis and functional studies this becomes a very prominent tool. This study describes various methods used in microarray technology and how the technology was utilized in studies of certain hereditary cancers together with supporting methods and technologies. Although DNA microarrays are used primarily in research, clinical applications are foreseeable and slowly emerging. This study should give more insight to the potential of microarrays as a tool for cancer research. The book should be especially useful for undergraduate or graduate students in the field of molecular biology or cancer research who wish to know more about the microarray technology and how it may be used in conjunction with other methods in genetics, or for anyone else who may be interested in microarray experiments.

Cancer Diagnostics with DNA Microarrays

Cancer Diagnostics with DNA Microarrays PDF Author: Steen Knudsen
Publisher: John Wiley & Sons
ISBN: 0470041099
Category : Science
Languages : en
Pages : 272

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Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

Expression Profiling of Human Tumors

Expression Profiling of Human Tumors PDF Author: Marc Ladanyi
Publisher: Springer Science & Business Media
ISBN: 1592593860
Category : Medical
Languages : en
Pages : 399

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A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

Microarray-based Gene Expression Analysis in Cancer Research

Microarray-based Gene Expression Analysis in Cancer Research PDF Author: Cecilia Laurell
Publisher:
ISBN: 9789171785428
Category :
Languages : en
Pages : 76

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Microarrays in Cancer

Microarrays in Cancer PDF Author: Michael F. Ochs
Publisher:
ISBN:
Category :
Languages : en
Pages : 72

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Application of High-Throughput Tissue Microarray Technology in Cancer Research

Application of High-Throughput Tissue Microarray Technology in Cancer Research PDF Author: Dan Xie
Publisher: Open Dissertation Press
ISBN: 9781374720923
Category :
Languages : en
Pages :

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This dissertation, "Application of High-throughput Tissue Microarray Technology in Cancer Research" by Dan, Xie, 謝丹, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of Thesis entitled Application of High-throughput Tissue Microarray Technology in Cancer Research Submitted by Xie Dan For the degree of Doctor of Philosophy at the University of Hong Kong In May 2004 Tissue microarray (TMA) is a new high-throughput technology which allows rapid and simultaneous visualization of molecular targets in thousands of tissue specimens at a time under highly standardized condition, either at the DNA, RNA or protein level. My objectives in this study were to (1) construct multiple tumor tissue TMAs containing a series of different tumor types and normal tissues from Chinese patients; (2) use multi-tumor TMAs to screen the expression of a novel candidate oncogene, eIF-5A2 by immunohistochemistry (IHC) and evaluate it's oncogenic function in tumorigenesis; and (3) test the abnormalities of some cancer-related genes, such as β-catenin, p16, E-cadherin, c-myc, AIB1, clusterin, EGFR and Tp53 in several tumor-specific TMAs, so as to investigate their clinico-pathological significances. In this study, I firstly constructed multiple tumor tissue TMAs containing a total of 4671 human tissue samples, including 1619 cases of primary tumors from 11 different tumor types, 234 cases of matastases or recurrent tumors from i 4 tumor types and 505 samples from 8 normal tissues. I then used IHC to screen the protein expression of EIF-5A2 in this multi-tumor tissue TMAs and found that the high-level expression of EIF-5A2 was more frequently occur in human cancer as compared to paired normal tissue or benign tumor lesion. In addition, high-level expression of EIF-5A2 was evaluated to be significantly associated with patient's later clinical stage in several tumor types including ovarian cancer, colorectal cancer, lung cancer and bladder cancer. These studies demonstrated that multi-tumor TMA would be extremely valuable to understanding the similarities and differences in biology of the many different categories of human cancer. In tumor-specific TMA, by using a progression colorectal cancer (CRC)- TMAs, I found that the expression of β-catenin and p16 was quantitatively increased from normal mucosa to premalignant adenoma, to primary carcinoma and to lymph node metastatic carcinoma, and the frequency of overexpression of β-catenin and p16 in lymph node metastases was significantly higher than that in distant metastases, suggesting that the overexpression of β-catenin and/or p16 might be involved in CRC lymph node metastasis but not in distant metastasis. Meanwhile, a significant correlation between overexpression of AIB1 and p53 and aneuploid DNA content in CRCs was evaluated by the same TMA of CRC. Similarly, by using a progression ovarian cancer-TMA, I observed that the ii frequency of up-regulated expression of clusterin increased from the normal ovary to adenoma, borderline tumor and invasive cancer. In addition, by using another tumor-specific TMA containing 2 subtypes of glioblastom, we revealed that amplification/overexpression of EGFR in Chinese glioblastoma may be associated closely with the patients age but not with the tumor's clinical subtype. All these results demonstrated that the TMA technology could provide an ideal approach in cancer research and it will facilitate rapid translation of basic research to clinical applications in the future.

Molecular Pathology in Cancer Research

Molecular Pathology in Cancer Research PDF Author: Sunil R. Lakhani
Publisher: Springer
ISBN: 149396643X
Category : Medical
Languages : en
Pages : 369

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The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classification of different tumors and identification of potential molecular targets, as well as how this knowledge may be translated into clinical practice, and the huge impact this field is likely to have in the next 5 to 10 years.

Feature Selection in Cancer Research

Feature Selection in Cancer Research PDF Author: Francisco González Navarro
Publisher:
ISBN:
Category :
Languages : en
Pages : 186

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